Confirming this on a couple of characters now. The first time was on the Defect, the second time on the mod Slimebound. I'm able to force movement to the next node by opening the map manually, but then the game CTDs. Reopening the game and attempting to load that run CTDs immediately again. I do have quite a few mods installed (66 I believe, at last count?), but the exception traces seem to keep pointing back to Infinite Spire. Unfortunately I don't have experience with StS interactions so I'm not sure what specifically to look for.

I threw the debug logs up on Pastebin just in case.

Snip of debug log from Continue to CTD[pastebin.com]
Full mts_process_launch.log: https://drive.google.com/open?id=1XBk3XwHK0kSDpzGUtj_A9eMcLZ5RZkPH

Also a post about it from another person: Weirdmicrocolony - Defeated Nightmare Alpha