Hi, I've sent u a friend request! I've seen you a lot on FNV forums but unfortunately non of those seems to have the same problem as what I'm looking for specifically. I'm really desperate at fixing my FNV man. I already did a clean uninstall - install of the game but it seems like the problem still persist from my past modded playthrough. I am now trying to play the game on vanilla, without mods and dlc. Also deleted FNV folders and MO2 folders after installing again. Would be awesome if I could talk to you more in detail about what my problem is to keep this comment short. Have a great day man, thanks for providing support to those in need on Steam forums (Reddit didn't help me at all). I hope you can help me. Thx.

Man you helped me so much throughout my gameplays, i hope you the best life

I love you

It can be a variety of reasons. Try to turn of "audio enhancements" in Windows audio—or, more precisely, tick the Disable All Audio Enhancements box. (If you are not on EN Windows, try google it and try to work your way through the menus.)
Once you start the game, Alt-Tab out and check the Windows Sound Mixer. Maybe it is muted by WIndows, maybe it is set to super low volume, maybe it tries to output to the wrong device.
Oh, and a final note,. the game does not like surround for some reason. If you have a surround setup, you may need to switch to 2.0 output only.

Hi, i'm having trouble with Fallout New Vegas could you help me ?
Even after totally desinstalled all mod and after redownloaded the game via steam; i have no music sound in the main menu and in the radio of my pip-boy. I have updated all my drivers. Thx

With your comment from ten years ago in steam forum, I was able to recover my Fallout NV save files, thanks for your help.