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The best brain depends on your play style.
Rey's brain can make Rex a semi-feasible companion in combat in non-hardcore. It is also the only male dog brain for this male dog. (If you don't count the fallback option, the NCR guard dog.)
Lupa's brain is good for hardcore in the sense that Rex dies about 5 seconds slower than normally.
Violetta's brain would be awesome if you could control companion behaviour. The speed bonus is actually quite nice.
The alternate way is to exploit some clipping bugs at the Hoover dam invisible walls, then do a few miracle jumps over some other invisible walls near the Legate's camp, which has a path to the Fort (not many people know it; the path is at the left from the main entrance, at the southern edge of the camp). You can just walk to the Fort then and get the brain any time. If you do this, be sure to NOT enter Caesar's tent or do so without getting near him, because he triggers the conversation of you starting the endgame, which can royally mess up a lot of quests.
It takes a lot of patience and practice to pull this off though, and having the Invisible wall remover mod helps a ton.
He was thinking more of being able to swap them like you can the OWB body parts.
I generally use Violla's brain because its... there. its like hey Rex you need a brain? Well I got one in my inventory cuz I picked it up, because I pick stuff up and I can't put it down. here you go boy.