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Or the tarantula upgrade on the sonic emitter if you are a critical hit build. In which case you have the constant decent possibility to one-shot anything, regardless of their DR/DT/HP.
If you have OWB, Elijah's Prototype Tesla Cannon hits like a freight train if you can aim it right. It even has a bonus against robots and power armor, which is something most energy weapons have an innate disadvantage towards.
The tri beam laser is nice especially with a post ED-E from lonesome road +5 beam damage (both to it and the laser gatling/SPTL wood)
The Gauss rifle is a toy. sure it does alot of damage but its slow to fire/reload, good for killing the 3 card bounty members but in usual practicality I'd prefer a laser rifle and just shooting more shots, or a holo rifle. (both upgraded)
The unique plasma rifle is OK
The GRA pistols are great in the first part of the game with a damage mod in them.
Novac has the Hyperbreder alpha. which is automatic like and requires no ammo.
But yeah Generally I have a tri beam if I want to kill things when they get 'close' and a scoped laser rifle with mods for sniping.
If you visit deathclaw's the Gauss rifle is a good choice.
The holorifle instantly stuns an opponent, but you should take a combat knife with you to slay the stunned opponents while theyre on the ground.
The laserrifle is good with modifications.
And I recommend to take the M16 (Dutyrifle) as well if you run out of ammo with armor piercing rounds.
If you can't tell which weapons are better yourself consult the wiki.
Cleansing Flame also has a strength requirement of 7, making weapons like it something of an anomaly. One of the biggest draws for using energy weapons is the comparatively low strength requirement.
If I haven't done any of the DLCs then I tend to carry the reliable laser rifle especially if I made a crit build character. I usually mod it with all but the scope but since I have the Weapon mod menu mod I can add/remove it at anytime if I do decide to use it. The only ammo I usually have for the laser rifle is the optomized cells to get decent damage and not to burn out the laser rifle like max charges cells.