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Unarmed has low weight so you can carry more weapons, some for robots or power armour, power fists for high armoured units and spiked knuckles for speed and low armoured enemies. You also have a few different unarmed moves that can be learned by various npcs.
They're both good, but I find unarmed to be more op in this game.
Other than that, you'll be abusing chems to become super OP in both builds. Using unarmed seems to be more useful though if you're looking to start trouble in casinos, due to the piss poor damage of holdout weapons and the fact that White Glove society doesn't allow holdout weapons unless stealth is at a high 50.
Unarmed has a selection of strikes(straight, hook, uppercut etc) but I don't know what effects those have other than being just a cool strike.
Both are viable, but IMO, melee is more fun
Melee has a wider variety in weapon options and you can have longer reach with it.
Melee also has the ignore armor weapons and rapid hit weapons like ripper, chainsaw and thermal drill.
With that being said, though. Those continuious attack weapons are fantastic even without the benefits of ignoring armors.
I am just doing a walkthrough with all the companions who can go in melee or unarmed(using Jip companion). It's hell of a fun :).
Wait, so you can raise your fist damage enough to handle enemies without a weapon(brass knuckles or power fists)?
I never did an unarmed playthrough, I always preffered melee.
For me personally, I prefer melee weapons more. With the right perks, the Blade of the West pretty much rag-dolls most of the enemies in the game (while at the same time doing good damage).
Weapons that rag doll effectively are basically over-powered.
On the other hand, the Industrial hand has some insane dps. So if you really like unarmed weapons, the IH is not a bad option.
Of course, the Thermic lance (which is a melee weapon) beats the Industrial hand in terms of dps. So there's that as well.
All in all, I say choose whichever is the most fun for you. Both unarmed and melee are very powerful later in the game. The weapon type that fits your character is the best choice imo.