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Like, perhaps you picked that preupgraded dagger spray for reptomancer, but the unassuming poison potion you didn't buy effectively dealt 40 damage to you in the giant head fight.
Something like that anyway. Deck size generally matters less than resource quality.
1: Hit up as many Merchants as possible, though make sure you time it so that you'll have adequate gold to use their removal service.
2: Hit up as many ? as possible. There are a large number of events which can remove cards, it'll also keep your temptation to add cards down.
3: Be extremely spartan in pickups. Just because it is a good card in a vacuum or is already upgraded doesn't mean you should take it.
It sounds to me like your problem is the ? events. While they don't always have remove a card events, they're a lot more common than Merchants.
You shouldn't be afraid to add cards to your deck. With a larger deck you will draw your terrible starter cards, curses and statuses less often. This becomes important on higher Ascension - the best players, who beat the Heart on A20, often end up with about 40 card decks.
I have a kid-in-a-candy-store approach when it comes to collecting cards and relics, and very rarely ever pass them up, so I decided to just accept it and account for it. I try to hit up the max number of elites, then shops, then ? rooms, and then rest areas. Fighting fewer regular enemies ensures that I have fewer cards to bloat my deck with, and also less gold to blow on cards at the merchant. I prioritize relics when buying things or mapping out my route, because they have a (usually, but not always, permanent) passive effect that doesn't rely on drawing them. I also prioritize power cards (especially ones that can be made Innate), since they stay applied after their first use and don't get placed back into the deck, which then reduces the deck size mid-battle. That's turned out to be a crucial tactic. And I try to favor cards that cost 0 or can be made to have a lower cost, and have several exhaustible cards so that I can do some more mid-battle bloat-reducing. Aside from that, just favoring cards that draw and discard. It's a very cobbled-together, improvisational balancing act, but it's effective if you stay mindful.
By picking the Pandora's Box relic and having your strikes and defends removed, and then clicking on the abandon run option, followed by hitting the ESC key twice, you will find the cards intended to replace the strikes and defences are not part of your deck.
This can cut out up to 9 cards of your deck if you haven't already started removing the strikes and defences, so if you ever see the Pandora's Box relic, try this exploit out. Worked for me as early as today~
For Iron Clad, there is Pommel Strike, Burning Pact, Battle Trance, Dark Embrace, Offering, etc, also exhausting cards is practically deck thinning.
For Silent, there is a lot, the most common being Back Flip, Acrobatics
For Defect, there is Heat Sinks, Skim, Scrape, Cool Headed, etc.
For Watcher, there are cards with scry, cards that shuffle a "draw two cards" into your deck, a power that draws you 2 cards when you enter wrath, attacks that draw card, etc.
It depends on your goal. If you're going for a specific achievement or self-motivated challenge, small deck sizes tend to depend primarily on luck (events that remove your starting cards + good RNG on card draws to get the cards you need quickly while skipping most).
If you're trying to win more, then specifically aiming for a small deck will probably negatively impact your win rate rather than improve it. There are many reasons for this, but here are some reasons why I personally consider large (>30) deck sizes to be better:
- In the early game, you often need to take cards that do not scale well in order to beat the Act 1 elites.
- Small deck sizes suffer significantly against curses/status cards.
- Small decks tend to be strong in specific aspect but weak in other aspects. This often means that if you get unlucky and are tested in an aspect that the small deck is not prepared for, you will lose that run.
If you're just trying to improve your win rate, I recommend you focus on improving how you think about building a deck rather than things like size or themes.