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Also, skipping elites often means more hallway fights, and later hallway fights in a given act often have the potential to do just as much or more damage than the elites will.
My favourite setting at the time was the "getting relics instead of cards for battle reward", because it was cheating (lol). That's why I opened this thread because I want to know how to play this game properly.
I mean, why would the devs make more elites if we're supposed to avoid them if possible? It just didn't make sense.
Unfortunately, guides can be made by literally anyone, regardless of whether or not what they are telling you is any good. The same goes for advice given on the discussion boards. Make sure you verify that the person is credible (so, for instance, someone who keeps deleting their posts might not fall under that category) before even considering their advice. Khor, faceplant712, Lupus Albus, Zu, and some others tend to be very reliable when it comes to their game knowledge so I'd recommend reading their responses to questions. Some of the other stuff that they say though...
Eventually you learn when you can safely fight an Elite, when you can't justify fighting an Elite and when you probably can't beat the Elite, but you really need a relic to make your deck gets good enough to hopefully beat the run eventually.
Point is: it's not an exact science and it depends completely on how well your deck is doing right now (including HP, potions and relics in this case).