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The main storyline can always be completed, regardless of who you kill, but all (except the Sarsaparila one, I think) the other quests can be failed by killing important characters.
On an unrelated note, I like your guide :3
The main storyline does, in a sense.
Manny Vargas is a good example of this, actually.
You can either persuade him to tell you where Benny went through dialogue or completing his quest.
Or you can hack his terminal in his motel room and get the information from there.
Or you can pick his pockets and get a slip of paper (or holodisk) that tells mostly the same thing.
Or you can kill him and loot the aforementioned item from his mutilated corpse.
Or you can just randomly stumble on Boulder City or just skip all that and wander to Vegas and skip that entire part of the main storyline.
(And some people say NV is linear...)
Side quests just give that "Quest X failed" message if you kill or piss off someone integral to it.
Cool, glad you like it!