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If you're worried about Melee/Unarmed being less effective against things like Deathclaws, knockdown is the answer. It's essentially stun-lock and is a death sentence for any enemy even Deathclaws. You can get knockdown from the Super Slam perk at Level 8, or learn the Ranger Takedown ability from Ranger Andy at Novac. There really is no way to go wrong in this game except blowing all your SPECIAL on Charisma.
This. I recently started the "Crit Build-ALL SKILLS 100-Energy/Explosives/Unarmed" By John from the Guides section. I'm quitting and starting a new save. This build is too compromised. He focuses on Unarmed early, but not fully. You can't specialize in three weapon types and have all of the perks for that weapon class and combat skill, even after omitting the VATS perks.
Getting the perks that focus on melee combat requires investment in both Unarmed and Melee Combat.
Also, I think that if a Stupid character uses the Skill Trait, it should help with giving more skill points in all skills.
I think that it would be difficult and impractical to use explosives on their own and am thinking that it would be better to use them as a secondary combat skill rather than a primary one.
Probably the only builds that could pick up the perks for improving a secondary combat skill would be those that don't focus on critical hits, such as automatics or heavy handed combat as they use up less perk slots.
Something like guns + explosives can work well together, since both focus on killing things from a specific distance. Think of the "Grunt", "Cowboy" or even "Commando" perks and come up with a playstyle that reflects those character acrchetypes.
Edit: sorry for the deletes, some issue here.