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I may have spoke too soon, I don't remember all the details of the quests. I was doing YES MAN and some Legion this playthrough. Today, Ceasar was pissed i killed Big Sal and Nero.
From the wiki, in regards to For The Republic Pt, 2.
If Cachino has already been killed, it may not be possible to complete this quest with positive reputation, because Nero often disappears from Gomorrah altogether. This prevents the assassination of both of the Omertas bosses, and requires one to finish How Little We Know by aiding Big Sal. This results in Strip Infamy, and one must lie to Colonel Moore about their plans.
And possibly keep good karma and rep with the strip?
Not exactly sure. I would still try to complete the quest for Big Sal, then go and lie about it to Moore.
Sorry if I disrupted the thread, I personally hate these final quests involving the casinos right before the final battle at Hoover Dam.
(I went back to my oldest save, just after Cachino died)
The Strip reputation doesn't really affect the game at all, so that's up to you. Good luck.