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For weapon: Just get highest dam / dps weapon you can find.
First of all are stats
7 strength (+2, -1)
4 Perception (+2, -1)
8 Endurance (+2, -1)
2 Charisma (+2, -1)
7 Intelligence
5 Agility (+2, -1)
7 Luck
Early Bird Perk
Wild Wasteland Perk
Melee weapons are easier than fisticuffs but I will list the best melee weapons in ranking order that I've found.
1. Photonic Inversal Axe
2. Knock-Knock
3. Katana/ Gehenna
4. Nephis 9 Iron
5. Old glory, nuka breaker etc
6. Chances knife
5. Anything else
Weapons to avoid
1. Chainsaw
2. Ripper
3. Thermic Lance
4. Super Sledge
Fisticuffs weapons
1. Pushy
2. Two Step Goodbye
3. Fist of Rawr/Embrace the Mantis
4. Super heated Saturnite
5. Love and Hate.
Places you need to get to ASAP
Followers medical clinic, you should be able to handle all 8 cyborgnetic implants.
BIG MT for the Proton Axe
Happy Trails for unique melee
Fiend territory is good because you can get love and hate along with nephis 9 iron (theyre so good)
Why avoid the listed weapons? Simple reason zero knock back. As a melee only build you rely heavily on knocking an enemy on its ass and chewing its limbs apart. So far I've successfully killed the legendary Cazador, Took on several deathclaws single handedly including patriarchs and giant Scorpions etc.
The tactic is to go heavy on the first swing, then chop them when they're done. Don't over use VATs as it'll get you stuck in an animation and you won't be able to dodge against mobs.
Chop chop lasted me from level 20 to level 46 when I replaced it with the proton inversal Axe. You literally don't need to carry any other weapons.
Time your swings right and you can sell every laser gun, mini nuke and minigun you come across.
Cook cook's stew
Brahmin steak
Battle Brew
Large Wasteland Tequila
Sierra Madre Martini
Ant Nectar
Blood shield (cazadors)
Buffout
Healing Poultice
Rushing Water
And most importantly
Weapon Binding Ritual xxxxx
Lastly worth covering is armor, Riot Gear Armor all the way, power armor will slow your character down meaning you can't really run up to people (could somebody source that actually, idk if it has an impact?)
Poisons.. aren't really worth it. They're an interesting addition but unless you're planning on taking a pack of Yao Gaoi at level 6 I don't see much point to them.
Pay attention to the following skills
Sneaking
Melee weapons
Unarmed
Survival
You'll need all of these high to make the needed chems and perks that boosts melee damage. Make sure to read carefully and pick ones that boost swing speed, damage or has unique fighting abilities.
Avoid any perks that boosts your gun damage, you don't need them. And stay clear of AP boosting perks too