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Personally, I'd do (with no specific build in mind) cha/ag/luck/end and the DR boosting one. But that's just me.
I could be wrong, but aren't there only two points of end you can get in the game? One from intense training, one from one of the DLCs.
Edit - NVM, just need to burn more perks.
You can use Intense Training on the same stat multiple times. And there is one from the implant though it doesn't increase the "slots" you have.
Yah, hence my edit :D
The implants work as such - you get one for every point of *base* endurance you have, and you can't stack implants. For example, if your END was three you could get an INT, a LCK, and a STR, but not 3 INT. Because it's base end (i.e END from your staring endurance plus any points from the intense training perk), you can't give yourself a free endurance with the endurance implant.
There's a few things the 'pros' might consider - strength reqs of weapons, requirements for specific perks at later levels that are useful to their build, and more generally just stats that are build relevant. For example, if you mostly use melee weapons, then strength could be construed as good because it will make you do more melee damage. If you're using mostly guns and have mid-tier strength, upping strength might help you meet the strength requirements for some heavier guns, which are usually the kind of gun that does more base damage.
If you haven't planned that far ahead and don't really know what you're going for, the best stat is probably INT. INT affects the amount of skill points you get each level, so having high INT means more points, which is nice. An extra luck point will also generally help every build - it ups critical hit chances and also influences blackjack results. 8+ luck characters can make thousands of caps on blackjack tables with minimum effort.
Charisma is bad. All it effects is speech/barter skills and companion damage. The effect on skills does not matter in the slightest, because you can simply add points to skills whenever you level to negate this problem - pretty much all my runs end with me having 100 speech but 1 charisma. Companion damage is good early game even at 1 CHA, and lategame you're going to outpace your companions real fast once you're levelled so they hardly matter anyway.
If you're a melee/unarmed weapon user, the sub-dermal armour implant is also a pretty viable implant option as well as the stat ones. +4DT is not to be sniffed at if you're constantly running at opponents with guns.
Depends on how you play. With my current setup, lower level cap, and difficulty set pretty high via a slew of mods - companion damage and having those points to put other places is very, very useful over using speech/barter as my primary stats.
Vanilla? Sure, maybe skipping CHA is the best idea. I'd still rather set it midrange or higher.
IMO Perception is the one I'd usually skip personally - once you have ED-E, seeing stuff on the compass is no longer much of an issue, and PER dialog checks aren't the most common.