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The red hills north of the river also have a load of them. Just mind the deathclaws that also make a home up in that area.
They have smaller nests here and there, but you kinda have to search them out to find them most splaces, or they refuse to spawn in favor of fire geckos or deathclawhs.
clear out that small abandoned ghost town full of viper members and cazadors will takeover
the entire Left side of the map on red rock canyon is literally cazador central
Theres a cazador nest marked cazador nest on the right side of the map once you find it
wind farm where all the windmills are is another area they usually respawn in.
Lastly bitter springs (the areas to the left and below near the lake) are riddled with them especially near the boat yard where you go to to activate the beacon to get the plane up from the waters for the boomers.
They all respawn if you give them a day or 2. Best option is to sleep (in your own bed for extra xp too) and take a crap ton of antvenoms, slashers, and stimpacks, you'll need em especially antivenoms b/c the venom sticks to you and does more damage than the sting itself.
The tribal village (area north of goodsprings) usually has a ton of them near the great khan encampment and north (again it's mostly all red rock canyon territory so you'll see a metric ton of them.
aside from that literally any place you see a cazador nest (a paper wasp-like nest with a ton of nodes sticking out) memorize the place and come back to it in 1-2 days. They should respawn by them.
What i like to do is place some c4 around the area and some landmines. Dedonate the c4 and the landmines go with it.
Yes. Opening the console does disable Steam achievements, but these can be re-enabled by simply quitting the game and relaunching it. Mods don't hinder achievements (or challenges) at all on their own.