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Lucky 38 does have some bugs that can be hard to work around anyway.
It might be worth a shot to lower you graphic settings to low and give it a try.
Beyond that there is disabling mods in small increments, though that is a variable risk for greater problems.
GameMode=FalloutNV
FalloutNV.esm=1
DeadMoney.esm=1
HonestHearts.esm=1
OldWorldBlues.esm=1
LonesomeRoad.esm=1
GunRunnersArsenal.esm=1
ClassicPack.esm=1
MercenaryPack.esm=1
TribalPack.esm=1
CaravanPack.esm=1
FreesideOpen.esm=1
New Vegas Redesigned 3.esm=0
Run the Lucky 38.esm=1
Monster Wars.esm=0
AWorldOfPain(Preview).esm=1
Momod.esm=0
enclavebunker.esm=1
DFB - Random Encounters.esm=1
mojavereloaded1.esp=1
Gomorrah Redesigned v2.esp=0
NVStripOpen.esm=1
AWOPDeadMoney.esm=1
SolidProject.esm=1
Bitter Springs Redesigned.esp=0
Casa Madrid Redesigned.esp=0
Companion Core.esm=1
RobCo Certified.esm=1
SpeedyResources.esm=1
Mission Mojave - Ultimate Edition.esp=1
Level100PerkPerLevel.esp=1
New Vegas Redesigned 3.esp=0
Legion Quests Expanded.esp=1
The Lucky 38 Empire.esp=1
FreesideOpenPatch.esp=1
Fellout.esp=1
Area 51.esp=1
CASM.esp=1
MoMod-MCMMenu.esp=0
GaiMagModded.esp=1
Reload Sounds.esp=1
IronSightsFoley.esp=1
SneakFoley.esp=1
FortBeachOpen.esp=1
TopsToVault21.esp=1
LonesomeRoadScorchedSierraPowerHelmet.esp=1
L38UpgradeTerminal.esp=1
Zan_AutoPurge_SmartAgro_NV.esp=1
RenamerTool.esp=1
LootMenu.esp=1
rotfacetoriches.esp=1
kochandbohr.esp=1
betsybrahminFSO.esp=1
CNR_Beta.esp=1
StripOpenMain.esp=1
MMUE-CP-AWOP.esp=1
Alternative Start.esp=1
Long15RebornALPHA.esp=1
DLCCompanions_1_3.esp=1
DLCCompanionsNoWaitSandbox.esp=1
VulpesCompanion.esp=1
Monster Wars - More Robots Plugin.esp=0
BlackjackPackULTIMATEv2.esp=1
FO3WeaponsRestoration.esp=1
AWOPDeadMoneyVendorPatch.esp=1
Dino Jackson Action Star.esp=1
MojaveReloadedBattleEdition.esp=1
ZB245 Gun Pack.esp=1
Aegis Oil - Oil Rig.esp=1
VincentVincent.esp=1
IncreasedLegion1_1.esp=1
RandomInvasions.esp=1
hunter.esp=0
MoMod-NightSpawn.esp=0
The Mod Configuration Menu.esp=1
Vault Archives.esp=1
Monster Wars - Behemoth Rampage.esp=0
Deathclaw Mutant.esp=1
Patch.esp=0
TrooperOverhaul-Dragbody.esp=1
AWOP-MoMod.esp=0
pipboy2500_edisleado.esp=1
Bubba shot the jukebox.esp=1
longerdeath.esp=1
ArcadeAfterQuest.esp=1
3DNPC_HopeLies.esp=1
NCRTrooperOverhaul.esp=1
Book of Steel.esp=1
Brotherhood and House Alliance.esp=1
return_deadmoney.esp=1
athornysituation.esp=1
MojaveEnclavePatrols_v1.0.esp=1
NewVegasBountiesFSOPatch.esp=0
awilderwasteland.esp=1
Monster Wars - Colossus Plugin.esp=0
AWOP Interim Fixes.esp=1
TUNNELERS MOVE TO NV.esp=1
Cazaclaw Resource.esp=1
TUNNELERS MOVE TO NVpart2.esp=1
inquisition.esp=1
Ultimatum.esp=1
Monster Wars - Behemoth Respawn Plugin.esp=0
Assassins v1 The Organ Harvesters.esp=1
JJRexBrainSwap.esp=1
RobCo Certified Friendly Hit Fixer.esp=1
Uniforms of the American Civil War.esp=1
CAGE 1.9.3.2.esp=1
AmericanRevl.esp=1
HellFire Armor.esp=1
Cerulean Robotics Playerhome.esp=1
robcorufusloboshopfix.esp=1
Centered 3rd Person Camera - Unraised.esp=1
DetectedByWhom.esp=1
DFB - Random Encounters - Update - MCM.esp=1
DLC Weapon Integration.esp=1
XFO - 9a - Enemies - AI revamp.esp=1
XFO - 9da - Enemies - NPC Healing - low.esp=1
XFO - 9db - Enemies - NPC Healing - med.esp=1
XFO - 9dc - Enemies - NPC Healing - high.esp=1
Fellout-OWB.esp=1
friendofnightforfellout.esp=1
HazmatCloudImmunity.esp=1
FortKeepWeapons.esp=1
KillableKids.esp=1
TrueHometownHero.esp=1
StripEnemies.esp=1
NoFactionArmor.esp=1
QuickHacking-NV-FullXP.esp=1
QuickHacking-NV.esp=1
Sprint Mod.esp=1
Fully Functional Ghoul Race Mod.esp=0
Playable Marked Man.esp=0
marked_man.esp=1
MarkedMan.esp=0
ReElijahfied.esp=1
Grab Everything.esp=1
AAACourierRiotGear(Craft).esp=1
DEagle.esp=1
Hooded Hazmat Cowl and more.esp=1
hazmatsuiteffecttweaksv2.esp=1
EVE FNV - ALL DLC.esp=1
Guyguyga Strip Control.esp=1
B42Inertia.esp=1
hazmatsuitandhelmettweaks.esp=0
AWOP-FCO3.esp=0
hazmatsuiteffecttweaks.esp=0
JIP MiniMap.esp=1
JIP Improved Recipe Menu.esp=1
JIP Companions Command & Control.esp=1
HelplessFalling.esp=1
avangraffscorned.esp=1
FSOmusic.esp=1
AWOPFSOPatch.esp=1
Pacersgambit.esp=1
Some mods I'm not familiar with but anything related to Lucky 38 directly and maybe the camera mod, I'd start with first -- without looking them up. The big mods/overhauls should be OK. You can probably scratch a lot of the list of culprits -- such as companion mods, even though those are known to be big issues in other games or other places. That is unless one of them is expecting a companion but I would think the crash would happen before this point.
I think it might be a badly damaged script or something like that, because I made a new character and went straight to the 38 control room and everything worked fine, as opposed to trying to kill Mr. House for the Wild Card Quest, which was when I was crashing.
EDIT: Someone already posted about it