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As always, take lots and lots of drugs to really be effective.
the Tribeam laser shoots 3 beams with reasonably close spread for 'close' encounters (the multiplas has more spread if you want more spread)
The Gatling laser does ALOT of damage per second. the Unique one does less damage per second but more damage per beam.
Regular laser rifle is great at all ranges.
Ammo's slightly heavier but what else are you carrying? Never understood why people would use the Ballistic weapons except they don't understand how to make energy weapon ammo? just go to a workbench take your ammo and switch it to what you need.
I usually do optimized rounds for the reduced weight and weapon degradation, but the max charge rounds are preferable if you are going up against DT targets which is kinda of the point of energy weapons.
I mean Guns are great with like a 9mm SMG and JHP rounds for taking down soft targets. and Energy is great with Max Charge rounds for taking out hard targets, like radscorpions and legion hit squads.
The issue with Beams is there aren't cool unique beams. save maybe the holo rifle.
shouldn't be using guns if you want to melee though. I guess a laser rifle would be what I'd pick if I wanted a ranged weapon.
As for drugs?
"I've never actually used chems regularly because of addiction and side effects mostly."
Addiction is ignorable, either 1.) take more chems. 2.) pay 100 caps to a doctor. 3.) take a fixer followed by an antidote. 4.) suffer the minor penalty to stats.
Turbo is bullet time.
Med-x Slasher, Battlebrew is 85% damage resistance.
For one Endurance is a most for any close-combat character, and Unarmed also gets a score bonus from it, which will be helpful early on.
Drugs are completely unnecessary. New Vegas is not a game where you need to be 100% optimized in every concievable aspect. That said, Med-X will be very useful for tougher fights, and Jet + Purfied water can be combined via the Survival Skill (which also gets a score bonus from Endurance) to significantly boost your attack speed.
Spiked Knuckles will be your primary weapon for a long time. (The unique variant can be found in Bonnie Springs.)
Be sure to help out Ranger Andy in Novac so he teaches you the Ranger Takedown; the most overpowered attack in the game.
A Revolver or other high-powered Pistol makes a good ranged weapon, because in reality, your fists are going to be more than enough for general combat, especially if you make good use of the Ranger Takedown.
Have fun one-shotting nearly everything once you get a Ballistic Fist.
I've gone very high in strength and endurance and agility, and in addition to the obvious combat skills, I've levelled up sneak as well.
I've taken all the obvious perks that aid in melee and unarmed combat, and in order to aid in my explosives, I have taken both Burden to Bear and Strong Back, and I carry with me all the big explosive launchers, and large amounts of ammo (playing on hardcore). With Heavyweight (perk from Dead Money) and the Fatman-Little Boy kit, the Fatman weighs only 7.5. It's kind of amazing using it with some small bit of regularity. Almost never used to use it with other builds.
A good thing about levelling up both unarmed and melee is each skill is required for some perks that would affect both, so if you never levelled up melee for example, but you were playing unarmed, you'd miss the Ninja perk, which requires Sneak and Melee. Likewise, Slayer requires 90 Unarmed but affects both Melee and Unarmed. Of course, none of this is strictly necessary for a good build, but I did enjoy being able to take advantage of some of these perks for both skills for the first time, after playing this game for half a decade.
If you were to take Pyromaniac, the Saturnite Fist Superheated and the Shishkebab become a fair bit more menacing.
My girlfriend made a melee-only build and has largely supplemented it with the CoS sniper rifle and basically no guns skill whatsoever. She does have high explosives. Like me, she's playing on Very Hard and Hardcore.
Speaking of explosives, if you have GRA, the Mad Bomber perk lets you make some great stuff. MFC clusters are brilliant.
I tend to use a lot of chems just because they're weightless and they're everywhere, but you don't need to. However, as said above, you do want to get Ranger Andy's takedown move.
My first unarmed build years ago was without any DLC, and Ranger Andy's manoeuvre was more than enough to get me through it, but it was much harder than with all the DLC. Implant GRX kind of breaks the game, for example, but at level 46, my character's getting old, so she's all right with it for the last bit of her journey.
My previous FNV game was with the Cowboy build about 6 months ago using the Trail Carbine, Chance's/Bowie knife and long fused dynamite. This thread is making me consider trying the Cowboy again and switching out the Trail Carbine for a six shooter.
Interesting (at least to me) after that game I went over to another old game love, Morrowind, and am playing a khajiit where hand to hand is my take down weapon, a spear does the actual killing when they're down and unconscious, and throwing stars are my 'get their attention' weapon. Not really too different then the FNV builds described here. When I'm done with Morrowind I'll probably be like the famous Terminator quote "I'll be back".
My favourite build in Skyrim was a Khajit with unarmed and shield skills. Great fun.
I always wondered why Skyrim didn't have more of the objective improvements New Vegas brought to the genre/engine as opposed to the other way round but that's true, the animations were lovely altogether. You ever try levelling up the shield skill? Most fun I ever had was the combination of the two.
P.S. I like how you referred to the unarmed build as a Khajiit build.
I did my first Skyrim run as sword and shield. The shield skills were my favorites and I love shield kill animations. Also, have you ever been fighting on a steep hill/mountainside and then used the skill where you hold up the shield and sprint into people? The enemy ragdolls down the slope and off the cliff so fast that it's hilarious. It's like a fus ro wtf.