I recently started a playthrough focused on Blindsight and synthetic pawns and as it turns out they don't work well together at all. Off the bat I can't perform the blinding ritual on either mechanents or personae. The ritual didn't even pop up at the ritual spot until I had some human guests around. The only blinded synthetic pawns I have are the ones that started blind from the colony creation menu. I used dev mode to spawn in several human/mechanent/personae colonists and only the human ones had the option of having the blinding ritual performed on them.

Even if I give bionic eyes to my synthetics using dev mode, I still can't perform the ritual. I haven't bothered testing if I can re-blind a synthetic that has had its eyes restored with a healer mech serum/bioregeneration (assuming either work on synthetics).

Blindfolds seem to be straight up bugged; of the three mechanents in my colony, only one of them could equip blindfolds. At first, I thought it was because it still had its vision sensors, but the other mechanent that also has its vision sensors can't equip blindfolds. A few days later (in real time) I tried equipping the second mechanent with a blindfold again out of curiosity and now it can also wear blindfolds but not the third mechanent that started blinded. I thought maybe there was some interaction going on with headgear, but even if I have them wear the same headgear or remove their headgear it doesn't change the blindfold's behavior.

Blindfolds are bugged on personae as well; both of my personae are wearing blindfolds, but only one of them gets the "blindfolded" hediff in the health tab, but they both have the "wearing blindfold" positive moodlet in the needs tab.