If a character with Pen Case relic only have 1 unupgraded card in his deck, choosing "Smite" at rest sites leads to game being soft-locked, as after first upgrade being done it immidiately promts second upgrade without any cards left to be upgraded.
If a character also posseses Cofee Dripper (a relic that forbids resting) the game will be softlocked permanently without any way to bypass rest sites.