Advice friend here, assuming you're in the US but some of these tips can apply to the EU as well.

First: Don't bother trying to hide all DNA evidence. As long as you're not in a DNA database already, you'll have much more time and get much further killing fast and moving locations rapidly. You'll want at least one car, as the best way to stall the police and investigations is to commit your crimes in spread-out locations. If your crimes are all in the same area, it is easier to link them to a single individual and easier for the counties in the area to request and share information. Ideally, you should be moving around frequently, and crossing state borders at least weekly. It takes a lot of time and paperwork for police across states to compile and share information and evidence.

If you're targeting specific individuals that are all in one specific area or have obvious connections, your best bet is to take as many of them out as quickly as possible. If the police catch on to who you're targeting, killing in that group again would be impossible. Try to avoid public assassination type killings, as those create mass panic and will tip off detectives and police that the killings are most likely targeted. Usually, leaving a victim/victims in their home will make sure they are undiscovered for a good while and give you enough time to leave the area.

While travelling around committing crimes, it's important that you follow traffic laws. Any form of traffic stop leaves a record, and if your car is searched or your face/features seen it can spell the end for you if any precinct is already searching for a perp that matches your description.

Leave your license plate unobscured, travel at a normal speed, and don't make anything dangerous/suspicious visible from the windows of your car.

If the license plate of your car is seen and linked to an attack, your identity will be known, so it's best to use a license plate you've stolen or that can't be traced back to you or a relative. If your car or license plate ends up being seen, you should ditch both and attempt to find a new car. It should be okay to take that same car outside the state, and travel around in it for a bit, but if/when your crimes are connected, searches will begin en masse and using the same car will pose a severe risk.

As for method, a gun is usually your best bet. If you can't afford a decent silencer, then be careful about where and when you use it, as it is loud and shots are typically reported in most areas.

Knives, bludgeoning and strangulation as well as other methods also work, but pose the risk of the attacker fighting back and injuring you or getting your DNA on them. If they scratch or damage you significantly, you will bear marks that the public can look for and use to identify you. And obviously, attack at night, so that recordings are of lower quality and there aren't as many watching eyes awake.

When it comes to lodging, don't use hotels or motels. Every NA police station has a list of them in the area and will be asking about your description and your car if they ever obtain information about either. It's best to park your car in a wooded or abandoned area if you can, and sleep in there.

This is all a creative exercise of course, I definitely don't have any experience with this and I'm definitely not suggesting you do any of these things

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