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Also, how hard is Keys mode/Act 4, with Ascension off, compared to regular Ascension? Roughly what sort of Ascension level is comparable in terms of challenge level?
I suppose it's to get more out of strong runs. You still climb if you die in act 4, so w/e.
As for what ascension does to act 4:
A3: Spear shield damage+. Spear hits 4 times.
A4: Heart single hit damage +5. Multi hit 15 times.
A8: Spear shield hp+.
A9: Heart hp +50.
A18: Spear shield artifact +1.
Shield attack gains 99 block, not equal to damage dealt.
Spear puts burns on top of your draw pile.
A19: Beat of death +1. Invincible -100.
If I’m confident my run is going to be able to clear act 4, it’s usually good enough to manage the act 3 boss 90% of the time. As you do more act 4 runs you’ll start to get a feel for if and when to start considering going for it. Just clearing act 3 is enough to clear the ascension even if you lose to the act 4 boss anyway so as long as your run is strong enough to clear act 3 you’re good.
As for comparing it, it’s a very unique act so it’s hard to really compare to an ascension level, and it also scales with ascension too just like everything else. It’s definitely the biggest challenge the game throws at you though, and takes some preparinf throughout a run to deal with.
Without keys you get : Victory ?
With keys you get : Victory !
Which do you think is actually winning?
I am not a fan of doing Heart runs, it's always the same challenge. I'd rather play on increasingly higher general difficulties.
It is also more challenging and more fun i believe.
With how difficult the higher ascensions are just trying to clear normally without shooting for the Act 4 boss let alone with it combined with the need for a a more specialized strategy just to even stand a chance against it (which you may not even be offered ways to get around some of the more nasty mechanics), personally would have to hard disagree here. Hell, once you hit A20 it’s not even a guarantee an Act 4 clear is even possible on every single run so it’d just make the whole thing even more frustrating to deal with.