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IF you are looking to get wins. Otherwise you just have to try something. Most of the time you will die. Just how it is right now. I have 80 hours, and really its just RNG and how well you know the cards and what you could get. Even then, you can be hard countered by a lot of common encounters if not running the meta.
Block control, Strength, Exhaust, Machine gun cycle for the Ironclad (HP loss builds are barely supported, HP loss cards are generally a bonus for Strength builds).
Block Control, Poison, Shivs for the Silent, with Discard being a possible archetype that requires a monumental amount of setup, is very hard to make work and often ends up being actually Block Control with a weird win condition.
Like it or not, runs that don't follow those archetypes are likely to end up dead in the water. I'm sure that will change as the game evolves though.
Now if i am at the beginning of a run, i will only pick up cards that are either deck defining, such as whirlwind, or cards that are generally good in all situations. Cards that are generally good in all situations could be Battle Trance, Shrug it Off, Ghostly Armor and Offering. Try to avoid picking up cards if they just seem like filler cards. Things change if you play higher ascension modes, but the core principles remain the same, you just have to be less picky about what cards to pick up.
Some deck types are better at different sizes also. Decks that play slower need to be thicker to protect against being flooded with status cards over time. Faster decks generally need to be thinner to ensure that you get your strong combos as consistently as possible.
Depending on where you like to put your risk factors, you might enjoy trying for an infinite combo deck. Problem is that if you don't start getting the cards for it early, you'll likely lose the run before the first boss. If I get an early Tactician card, I almost always try to go for an infinite Acrobatics/Tactician combo, for example (though that does require that your deck be less than 12 cards).
Act 1: focus on offensive cards or transforming basic cards (ie. strikes). Save gold and visit 1 shop if you have 250+ to try and get a good relic or card (ie. apophesis). Avoid elites if silent unless you get a good relic/transform/event.
Act 2: start building deck but as above, don't take cards that don't synergize or that require synergy that you don't have (ie. don't take poison cards if you don't have a poison based build or a poison friendly relic). Visit a shop or two to try and find some good relics/cards.
Act 3: take upgraded cards if they are good, otherwise ignore most cards. Visit a shop to try and find some good relics/cards.
Block builds are by far the easiest to win the game. Ironclad block + power type builds can be very powerful (ie. metalize + dual wield). Silent cycle/discard/block builds are decent too (ie. concentrate + acrobatics). IMO, Ironclad can have deck sizes above 30 (due to exhaust cards like iron grip) and work well, where-as silent works best with smaller deck sizes.
Silent has sadly less options on higher tier ascensions