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As for going for the heart itself, you definitely needs the right stuff to beat it, which really just means you should keep the heart in mind when making decisions the rest of the run. Certain deck archetypes have a much easier time than others, Poison Silent is much better than Shiv Silent against the heart for example. Exactly what you want depends on your character and deck, but being able to scale both offense and defense in some way is quite valuable.
Well, yeah. You don't get a "victory" if you don't beat the heart, you get a reset from Neow, Goddess of Resurrection (IIRC), and start over from the bottom. Your goal is in the title.
Lol, get more relics. Relics are key. You can't always make a good deck, relics cover your ass.
Woops you're right, I meant keys not relics. Obviously I always try to get relics!
I considered that, and decided that since you unlock the next level by beating Act 3, and don't actually need to win Act 4, I might as well go for the heart if it's convenient enough to do so. You get better and at handling everything Act 4 throws at you by doing that, anyway.
Yeah this was the big problem for me. When I was going for the heart I'd give up good opportunities for the key which would then make me fail earlier.
Since making this post I've been playing with the intent to beat ascension levels and only go for the keys if there is no other option, like being at a rest site with no need to heal or upgrade a card.
This has resulted in me getting to the heart twice and almost winning despite not trying because I'm never giving up good cards/moves to get the key.
The heart is brutal though, I think I could have won it if I didn't have to fight the elites just before. Those always drain me like crazy