Progression between runs

[Nathaniel Prime]

Do you get stuff during your runs that make the next run easier? Or do you just lose everything? Or something in-between, like unlocking cards but not starting with them?

[Raff.run]

Once you get enough progress with some character, you unlock a set of things (cards, relics) for that character on the next runs. At the start of the game, you can also get you up to 4 options to choose from (like "gain 99 gold", "choose one card from 20 and add it to your deck") if you got to the first boss on the last run.

There also is a specific event where you can stash a card to be picked up when you get the same event in any run after that point.

And lastly, you need to beat Act 3 with all 3 characters to unlock the final Act.

[Nathaniel Prime]

Thank you very much!

[Nibbie]

The last one. You get "xp" based on your score for the run, and unlock three or four cards/relics each "level". These get added to the pool of potential pickups for future runs, not added to your starting deck. However, there are only ~4 levels for each character, and you only need ~2-3 runs for each level, so the unlocks go by quick.

The only other real unlockable is Ascension. Ascension is the hard mode for the game. After doing something (I think either beating all three Act 3 bosses or beating the game as all three characters, but I could be wrong), you can activate ascension 1. If you beat a run with that enabled, you unlock Ascension 2, and so on up to 20. Each level adds another difficulty modier to the previous one, like "more expensive shops" or "start each run damaged". You can select any ascension number you have unlocked at any time.