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yes, an energy bonus is very useful - but between the first two acts you should be almost guaranteed to get a choice of one if you need it. and not all builds do.
It cannot be compared with permanent energy boost.
buff happy flower to 1 energy every 2 turns and elevate it to boss relic
elevate ice cream to boss relic
restore thread and needle to it's former 5 plated armor and elevate it to boss relic
downgrade tiny house to common relic
downgrade lizard tail and orrery to rare relic
First of all, energy relics are *nice* but not entirely necessary to win runs. I've had an A20 heart kill on 3 energy and others have too, so it's clearly not impossible to win on 3 energy. Is having >3 energy nice? Yes. Is it necessary? No.
Secondly, many of the energy relics are straight awful to take in Act 1 (Note: I give this list based on the A20 perspective since anything that works in A20 will work in lower Ascensions but not vice-versa). Ectoplasm/Fusion Hammer/Kite (to be fair, Kite is just awful to take)/Crown are all potential run enders if taken after the Act 1 boss.
Assuming you're in a vacuum -
Great Relics after Act 1: Inserter, Mark of Pain, Nuclear Battery, Philosopher's Stone, Ring of the Serpent, Runic Dome, Runic Pyramid, Sozu
Decent, Potentially Great, Potentially Awful after Act 1: Astrolobe, Black Star, Key, Coffee, Cage, Orrery, Snecko Eye, Choker, Lizard Tail (maybe)
Some things I find to be just straight awful: Kite (worst relic in my opinion as it actively works against you unlike every other relic), Pandora's Box (you basically gamble whether or not you want to lose the run).
Everything else tends to be subpar (or rather useless but at least not negative) without specific synergies but can be decent.
The problem with Happy Flower being a boss relic, is that boss energy relics require some sort of trade off. Happy Flower does not do that. It's just ocassional free energy with no negative downside. The same thing applies to Ice Cream.
5 plated armor is a godawful boss relic and would be another useless pick up added to the pool (which as is, there are plenty of useless boss relics).
I'd totally be okay with Downgrading Tiny House, but again, I think the idea was just to have some rather useless relics in the boss relic pool so that people didn't pick the exact same relics every run.
Lizard Tail and Orrerry are both surprisingly decent and should probably be kept as Boss Relics. Maybe make Lizard Tail a rare. Maybe (but then you'd have to find another mediocre relic to promote to a Boss Relic).
Therefore, Pandora's Box will typically reduce your deck's defense ratio (to everything) by taking a grouping of strikes and defends that is 1:1 (or better if you've already removed strikes) and on average reducing it to 1:3.
Edit: math is hard.
As faceplant712 mentioned, the random draw you get will often ruin the consistency of your deck. This may mean that you end up with very little in terms of defense (or potentially very little in terms of offense) meaning that on higher ascensions, that run is just over. Sometimes Pandora's box will win you the game right there... but more often than not, it's a death sentence.
The problem is that I focus on some early damage cards to get through Act 1 elites and boss. So I'm usually a bit light on defense. Removing all defense cards ends up being a death wish in Act 2.
But in regard to energy relics, I'm usually struggling in Act 2 and 3 if I only have 3 energy.
It generally depends on a lot of factors whether or not you'll be okay in Act 2 and 3 with only 3 energy. A lot of it depends on the average cost of cards in your deck (so if you have a ton of 2 energy cards, it's very painful playing on 3 energy). Snecko Eye is low-key very strong for decks like this.
Some other ways to work around this are to find ways to play high cost cards without much energy (Corruption/Havoc/Mummy Hand) or to generate energy in some manner (Concentrate/Various Relics/Plasma Generation/Adrenaline/Offering/etc).
Now on A20 Pandora`s i disagree, it`s definitely not Kite bad (as in working once in a blue moon)
Depending on the amount of mitigation already in your deck it can be a good pick (you are decreasing the quantity but increasing the quality). Similar to stuff a la Sneko Eye, you`re not taking it if your deck can afford it.
Also, if your alternative is something like Calling bell and White Beast, you might as well YOLO it as there`s a good chance your not getting past Act 2 Boss without a bit of luck... aaand it`s fun
How much mitigation do you really have at the end of Act 1 on A20? Usually maybe 1 additional source of weak and maybe one or two extra blocking cards. Pandora's is... a very risky pick-up. I don't like taking things that potentially just end my run. Kite does that with its off-chance of 3 card turns and Pandora's does that with the potential of giving you an extremely unbalanced deck or a deck with no synergy. I consider Pandora's to be slightly better if taken in Act 2, since by then your deck tends to be more rounded out and thus trading your remaining strikes/defends for random cards is actually not awful. Kite is still just awful all around though. I don't even think I've ever seen anyone get an A20 Heart Kill as Silent with Kite.
It's not a question "ok, I get random relic which dosen't suit my current build, too bad". I can accept poor balance between options as perk of "rogue-like" genre.
But this double RNG wall on deserved reward is unnaceptible. "Oh, you won by the skin of your teeth, here is Tiny House - don't feel reserved".
It`s not just cards, there are also relics.
Silent has a bloated deck, 2 starting mitigation, good cycle and a slightly higher defensive cards %
Defect can be very frosty
Ironclad`s beefy of its own
Most importantly, hallways fights favour aggressive decks and it`s better to have a few good blocks than a couple extra Defends. By the time you reach the Boss you should have stabilized (or died painfully)
PB isn`t a top pick, far from it, but is still better than nearly half of the Boss Relics
Sure it can screw you royally, but in the end it`s the classic "Play to win instead of not to lose"