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1) mark of pain can be a huge downside as the silent, there’s very little way to clean your deck as the silent. Also mark of pain ruins clash, it’s in the middle for me.
2) sozu is easily one of the best, there is some disadvantage as overall it will cost you health more than likely at some points, there’s many points where I find a fire potion would save me quite a bit of pain.
3) I consider this the best one. Card removal isn’t a problem if you prioritize encounters early on or target elites to try and get things like peace pipe. Also I can just avoid shops if I have this, not much of a loss.
4) cursed key is absolutely insane with curse synergy but otherwise it’s mediocre. Most of the time if I find my deck benefits heavily enough from the energy I’ll just take it and not open chests.
5) this is the worst one but it’s way over exaggerated how bad it is. Past Act 2 it’s not so bad. I actually won my first run with it once getting it after the second boss. Also the strength doesn’t matter if you go for a defense strategy as long as you can still pull of your high numbers. With the tori relic it’s an easy pick too, things like birds do nothing then.
6) this is just somewhere a little below the middle. Not seeing enemy attack’s can be an issue but it works similarly to philosophers stone, if you can get a combo going due to the extra energy or if you can go for a barricade blur strat none of the disadvantages ever matter.
7) velvet choker, it’s absolute garbage on silent like by far the worst relic in the game. On ironclad it’s alright, it stops you from making a combo deck but it’s good in a demon form / defense strategy.
Also it’s good to mention after you’ve taken one energy gain relic any other energy gain past that can absolutely break the game. I’ve had runs where I made a 5 card combo deck getting 6 energy a turn thinks to random boss relic choice. Not to mention I used sundial as well so I could pull of a 7 mana combo constantly by abusing draw.
mark of pain cant be acquired on the silent, it has a red outline in the relic collection.
If you are running poison/defense deck with limited card draw and some cost 2 cards like Flask it's pretty good actually and I got 1-2 Silent wins where I took it. Not every Silent deck is an infinity loop or shiv deck. That said it does work better with Ice Cream and some X cards in your deck (Malaise, Skewer) so if you hit the card cap you aren't wasting energy.
*Sozu, Ecto, and Cursed are obviously preferable as Area 2 picks. Its a tough choice though. Potions can easily save a lot of HP if used at the right time, no gold means missing out on buying a Relic with your Area 2 Boss winnings, and Cursed clogs your deck or worse. These are the 'workhorse' Relics I go for if Velvet isn't appropriate. Sozu and Ecto in Area 1, Cursed in Area 2.
*Mark is best in certain Ironclad archetypes (Immolate/Evolve), ok in large Ironclad decks, but weak otherwise. It is clearly superior to Cursed in Area 1 but the clogging just isn't something I find acceptable and would probably take Sozu and Ecto over it anyways.
*Runic and Philosopher are obviously bottom tier. They both more or less mandate that you take large piles of damage, whereas the others mostly mean having the occasional bad draw and missing out on some useful products.
Also I disagree heavily with the assertion that the +1 Energy Relics are best. Of the 15 other Boss Relics, 10 of them have only upsides (whereas +1 Energy Relics usually have stiff downsides) and 2 of them only have the downside of Transformation which isn't that big a deal when you are probably just mulching useless starter cards for which basically anything else is better.
I think a rework is in place. For example: "+1 enegry, -2 dex". Your average cardvalue is lower, so you need to play more cards do that same job. But you also play more cards for potential synergy.
The only boss relic I skip 99% of the time is the cursed bell. Unless you have curse synergy or are absurdly desperate (and think some particular relic could bail you out, I guess?) I see basically no reason to gamble on it. I also never take Pandora's Box, but that's more just cause I've never worked up the nerve to gamble my run like that.
Ironclad on the other hand I feel like picking up the +1 Energy is more essential, unless you are playing an Anger build or another niche option.
As a rule I will always take a top 1-3 energy booster relic at act 1 and no other boss relic makes such an impact in later encounters. If the downside is negligible, it's always worth it.