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Was screwed over with Snecko Eye so many times I just don't risk it.
That relic is "ok" once there are high cost cards in the deck, but at the early game it tends to ruin the entire run.
Even then, almost every time that I have traded the Relic for something else, I have regretted it, even when the replacement was decent.
Boss relics that IMO are almost always better (8):
Cursed Key
Ectoplasm
Runic Dome
Sozu
Velvet Choker
White Beast Statue
Snecko Eye
Black Star
Relics that are usually better but can screw you (5):
Astrolabe
Orrey
Pandora's Box
Philosopher's Stone
Inserter
Relics that are worse (5):
Runic Pyramid
Eternal Feather
Lizard Tail
Tiny House
Calling Bell
Seems like a pretty good deal.
Snecko Eye is pretty great on Defect. It's roughly a wash with your starting deck (but obviously much higher variance) as compared to having no relic at all. Drawing 2 extra cards per turn with random costs means you'll on average be able to cast about 3 of them.
But as soon as you start taking other cards, it gits gud. Defect has a wonderful crop of 2+ cost cards (Meteor Storm, Sunder, Glacier, Streamline, most of the powers, etc), and your best block card (Reinforced Body) is unaffected. My Snecko+Defect win rate is through the roof. It does lock you out of some strats, though.
On Silent I always do that unless there´s a reasonable trade-off for getting a Rare Relic.
On Defect I do that when there is no other reasonable Relic gain choise. So about a third of the time.