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Vitamins actually increase your resistance so yes it helps having excellent resistance vs poor.
I'd say, if you wanna risk drinking water from other sources than the pumps, at least visit a hospital for some antibiotics first; they're usually not hard to find. There are plenty of cooking pots, plastic bottles and tinctures. Desinfect bottles once and use them at wells and you can run across half the map without needing more water. Plus a lot of zombies have cans on them.