I'm running into an issue when this mod is loaded, my Ticks bog down and so does the speed. Cant go past 1 speed. When removed, I can go 4 with Smart Speed with no issue. May be a combo issue, as I have 500+mods.

@cbradshaw007
You are the second person which has problems with smart speed and my mods.
Sadly I can only answer the same: My mods do not touch anything time related and I can not recreate the slow-down. My 5 year colony can still run on 900 tps with smart speed (meaning dev speed / speed 4).

Is there anything related to this in the log? Do you get errors/warnings?

massive slow down when this mod was enabled, seems to be an issue with pregnancy? i think?

Rimworld dev console is not my strong suit...

"Exception ticking world pawn Unit #1. Suppressing further errors. System.NullReferenceException: Object reference not set to an instance of an object
[Ref EC0F419C]
at AV_Xenos.PawnUtility_BodyResourceGrowthSpeed_Patch.Postfix (System.Single& __result, Verse.Pawn pawn) [0x00028] in <afe8418d2bf34cf6bf323b222d24d45f>:0
at RimWorld.PawnUtility.BodyResourceGrowthSpeed (Verse.Pawn pawn) [0x000a4] in <630e2863bc9a4a3493f2eff01e3a9556>:0
- POSTFIX OskarPotocki.VFECore: Void VanillaGenesExpanded.VanillaGenesExpanded_PawnUtility_BodyResourceGrowthSpeed_Patch:MultiplyPregnancy(Single& __result, Pawn pawn)
- POSTFIX com.alphagenes: Void AlphaGenes.AlphaGenes_PawnUtility_BodyResourceGrowthSpeed_Patch:MultiplyPregnancy(Single& __result, Pawn pawn)
- POSTFIX RedMattis.BetterPrerequisites: Void BigAndSmall.GenderAndSexPatches:Postfix(Single& __result, Pawn pawn)
- POSTFIX Rimworld.Alite.EBSG.main: Void EBSGFramework.HarmonyPatches:BodyResourceGrowthSpeedPostfix(Single& __result, Pawn pawn)
- POSTFIX AV_Xenos: Void AV_Xenos.PawnUtility_BodyResourceGrowthSpeed_Patch:Postfix(Single& __result, Pawn pawn)
at Verse.Pawn_AgeTracker.CalculateGrowth (System.Int32 interval) [0x0001d] in <630e2863bc9a4a3493f2eff01e3a9556>:0
at Verse.Pawn_AgeTracker.AgeTick () [0x000ad] in <630e2863bc9a4a3493f2eff01e3a9556>:0
- TRANSPILER Krkr.RocketMan.Soyuz: IEnumerable`1 Soyuz.Patches.Pawn_AgeTracker_AgeTick_Patch:Transpiler(IEnumerable`1 instructions, ILGenerator generator)
- PREFIX SZ.Mech: Boolean Pawn_AgeTracker_AgeTick_Patch:Prefix(Pawn_AgeTracker __instance, Pawn ___pawn)
at Verse.Pawn.Tick () [0x0064a] in <630e2863bc9a4a3493f2eff01e3a9556>:0
- TRANSPILER Krkr.RocketMan.Soyuz: IEnumerable`1 Soyuz.Patches.Pawn_Tick_Patch:Transpiler(IEnumerable`1 instructions, ILGenerator generator)
- POSTFIX alt4s.alliesarehelpful: Void PawnTendAndRescuePatch:Postfix(Pawn __instance)
- FINALIZER Krkr.RocketMan.Soyuz: Void Soyuz.Patches.Pawn_Tick_Patch:Finalizer(Pawn __instance, Exception __exception)
at RimWorld.Planet.WorldPawns.WorldPawnsTick () [0x0003e] in <630e2863bc9a4a3493f2eff01e3a9556>:0
- PREFIX Krkr.RocketMan.Soyuz: Void Soyuz.Patches.WorldPawns_Patch+WorldPawns_WorldPawnsTick_Patch:Prefix()
- POSTFIX Krkr.RocketMan.Soyuz: Void Soyuz.Patches.WorldPawns_Patch+WorldPawns_WorldPawnsTick_Patch:Postfix()
UnityEngine.StackTraceUtility:ExtractStackTrace ()
(wrapper dynamic-method) MonoMod.Utils.DynamicMethodDefinition:Verse.Log.Error_Patch3 (string)
Verse.Log:ErrorOnce (string,int)
(wrapper dynamic-method) MonoMod.Utils.DynamicMethodDefinition:RimWorld.Planet.WorldPawns.WorldPawnsTick_Patch2 (RimWorld.Planet.WorldPawns)
RimWorld.Planet.World:WorldTick ()
(wrapper dynamic-method) MonoMod.Utils.DynamicMethodDefinition:Verse.TickManager.DoSingleTick_Patch3 (Verse.TickManager)
Verse.TickManager:TickManagerUpdate ()
(wrapper dynamic-method) MonoMod.Utils.DynamicMethodDefinition:Verse.Game.UpdatePlay_Patch3 (Verse.Game)
(wrapper dynamic-method) MonoMod.Utils.DynamicMethodDefinition:Verse.Root_Play.Update_Patch1 (Verse.Root_Play)"