I really enjoy the "little" things in RE2. Yesterday I came across my first "cozmozoan" floating around in a exotic system, and I've found several random space anomalies in various sectors. But even with the scanning station / science stations, I've found no way to interact with these rare-ish features.

So I'm always worried there are interesting quests / lore / items I'm missing by enjoying the scenery and moving on. Does anyone have any (mostly spoiler free) advise on how to separate dungeon color vs something important? Like are there any non-obvious quests that one could easily miss if you didn't know you have to something? Or does it all come from POIs and/or talking to guys with yellow arrows over their heads?