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I could probably do it but even a -25kg weight perk would be hard to balance around a complexity/metabolism value because of how much of an effect it can have. Especially now that hauling AI was improved to grab things along the way, having very little spare weight could slow things down a lot.
The main reason is, that one essential feature of biotech is being able to "overwrite" gene expression by using the a negative (i.e. psychically dull would overwrite psychically sensitive, thus freeing up metabolism points). This also comes into play when creating custom xenogerms, where the metabolism cost might get out of whack due to having say packyderm in the same pack with something else you want, then adding the "Meek" gene could turn that into a net +4 metabolism for that xenogerm for example.
It's just one of the fun parts to fiddle with, being able to mute certain genes and I think the mod would be better if that was included (obviously -25 carry weight is not desirable, but it would be a valuable option and make for interesting choices).
Cheers!