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I'm not an expert on the lore or anything, I'm not sure if the actual SCP page for 106 says why it has to be the femur or not, I'd just guess that 106 may be able to tell the difference between fake screams and real ones, as well as know where people are (He can follow you in CB without line of sight, and pop up behind you and what-not, so that suggests he can detect you)
Femur is a bone in the human body, I believe it's in the leg.
http://www.scp-wiki.net/scp-106
In the event of a breach event by SCP-106, a human within the 10-25 years of age bracket will be prepped for recall, with the compromised containment cell being replaced and restored for use. When the cell is ready, the lure subject will be injured, preferably via the breakage of a long bone, such as the femur, or the severing of a major tendon, such as the Achilles Tendon. Lure subject will then be placed in the prepped cell, and the sound emitted by said subject will be transmitted over the site public address system.
SCP-106 will typically begin to gravitate toward the lure subject within ten to fifteen minutes after hearing the subject. Should SCP-106 not respond to the initial broadcast, additional physical trauma is to be administered to the lure subject at twenty-minute intervals until SCP-106 responds. Multiple lure subjects may be used in the case of major breach events.