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Just get a standard invincible god run going on, buy all the lunar items that won't get you killed like Gesture, Rachis, Corpsebloom, Convergence, etc. and use the dream portals to always go to swamp on stage 2, scorched acres on 3 and siren's call on 4, as those seem to be the only stages that can spawn cleansing pools. Feel to blast through stage 1 and 5 as quickly as possible.
I took advantage of the red spikes around interactables during the teleporter event to assist in spotting the pool, and I'd also recommend Drizzle to reduce the odds of a Scavenger one shotting you with equipment after you've invested so much.
It's worth noting that 1.0 increased the spawn chance of 3D printers pretty dramatically, which in turn decreases the spawn chance of everything else. For reference, I used to find at least one Cleansing Pool per loop before 1.0. One per run feels pretty lucky now.
Since the drop rate of Irradiant Pearls are at 4%, it's statistically not unlikely that you might have to spend 100 "attempts" before you even get a single one. That ends up at a lot of Lunar Coins.
I went on Cleansing Pool hunts before 1.0 with a Radar Scanner and even after around 60 removed items, no luck. Then just the other day, I saw a Cleansing Pool and pinged it, "Irradiant Pearl", and I had no lunars as well as no pods on stage. Next run I experience the exact same, but there was a pod on stage, and you can bet your saving I prioritized the log over the run, cause I knew I would not get the chance again for the next 50 hours.
Mithrix with an Irradiant Pearl is hell.
https://steamcommunity.com/sharedfiles/filedetails/?id=2220514096
And since you cannot use artifact, good luck getting decent choices in the shop.
Thanks! I thought sacrifice removed the pod, good to know it doesn't not having a million interactables on a stage clogging up your view will definitely help!
These bloody chances are haunting me more and more after the 1.0 update came, especially since I have yet to get the irradiant pearl (and I haven't made a run dedicated to it properly).
https://imgur.com/a/W7odwMb
I know exactly how u feel, im playing on ps4.. i didnt realize ps4 still has the 4% chance
https://twitter.com/Overlord_Renn/status/1533973139079806976?t=FH06NR2Lht7hNkztxJkQRg&s=19
This just insanity..