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Corpsebloom is wonderful for struggling through a loop of monsoon, but it's not very handy if you're gonna be doing like 2 hours of gameplay. Because yeah, you heal to full if you play for that long, and limiting incoming healing hurts.
Transcendence is in a boat just like it. You'll heal to full HP immediately if you can not get hit for a few seconds, but in exchange you can't get any incoming healing. It's a trade-off.
Corpsebloom: heal +100%(+100% per stack) more. All healing is applied over time. Can heal for a maximum of 10% (reduced by 50% per stack) of your health per second.
This means you gain 100% more healing from every source (anything that would heal 1 now heals 2) but this healing is aggregated together and applied over time, maxing out to 10% of your maximum health per second; Any healing beyond this is stored and used 10%/second at a time until the extra is gone. It's fully explained.
Transcendance: Convert all but 1 health into regenerating shields. Gain 50%(+25% per stack) maximum health.
This one tells you it increases your health by 50%, but turns all of your health into shields- Healing applies to your Health, NOT to your shields, so of course you can't heal via the myriad of healing items, that is the drawback to this item. It's a risk vs reward scenario, You're risking your healing via all those items for the reward of being able to avoid enemies for a couple seconds and the shield regen kicking in and fully refilling in about a second or so. Is it a great choice? not always. But if you're lacking any healing items, it may well be the difference between a win and a loss.
If someone can go in and get out fast, transcendence is pretty good since you can just immediately disengage until you have all your health back.