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After testing it myself, Vitality mantle DOES help with the nuke. I expected it would, because it's essentially an invisible max health extension that you can't restore.
I think that a perfectly timed Vitality Mantle + Astera Jerky eating + Health Booster can allow you to survive the high-power version of the nuke. However, you'd need to time your jerky eating very well in order to heal when you have an absolute fraction of your max health remaining.
so you survive or?