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Take accuracy on line 1 (and the born ready perk to help with reloads) with the extra ammo mod on line 4. Take floating barrel on line 2 for the greatly reduced spread per shot, now you can quickly dispense of multiple mactera without waiting to recover accuracy and you can more accurately ammo dump for burst damage on tough targets at range.
Grab hollow-points for extra weakpoint damage and dead-eye so you can accurately shoot mactera and menaces while moving/jumping/evading.
Common overclock for this setup is six shooter.
If you wanna roll with a "just a more accurate sidearm" kinda weapon like you asked, using 23311 upgrades (and with the six shooter overclock once you unlock it), you can easily enough headshot/takeout the lone glyphid, mactera, or webber on the ceiling. You could take the floating barrel upgrade for line 2 instead of extra ammo if you have trouble rapid firing, waiting for the spread recovery
It really shines in taking out big targets like praetorians and anything tanker. Using 21321 for upgrades will make this delete bigger foes, this is amplified further with the elephant rounds overclock you'll unlock later on if you haven't already, upgrades are basically the same except you'll want one of the ammo upgrades
Syncourt guy above basically explains it a bit better if what I said is too confusing
For me I use 6-shooter as my default, specifically with extra ammo but with enough damage that it can 2-shot a grunt on centre of mass on haz-4/5. That's just generally what I use as standard and the main things I'm concerned with because for the most part it's a backup weapon, a sidearm.
Other times, usually on a specific kind of mission with more unique parameters like a specific deep dive or set of mutators I may take something like elephant rounds because I have a specific requirement that needs handling etc.
Builds change, you need to assess yourself holistically relative to the parameters of the mission, good players will also take into account what their team mates are carrying because they'll be fighting as a team most of the time.