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If you're trying to lure away the 3 guys on day 5, make sure the quest updates appropriately (there are some tips for that in the above thread). You can also just kill them to be sure, but I'm not sure whether that has any consequences later on.
I can't find where exactly I read this but I'll keep looking for it.
Rubin dies on the eve of day 7 if you failed to "complete" act 3. There are several plot threads you need to follow up on:
-Did you fix the alembic (big machine) in your house?
-Did you subsequently create several antibiotic serums and test them?
-After all that, did you take a restful nap?
Nope none of those, I fixed it completely on my 1st playthrough but didn't bother much with the antibiotics or with the sleeping, just kept ODing on coffee
Brew one of each infected organ (don't forget infected blood too). Then, test all of them on the infected. One of them has to be the cure, right?
Ever heard the term "sleep on it"? Do not neglect the power of dreams. Seriously, they're really important... people have been known to achieve breakthroughs when the rest.
And what better place to sleep than your own home (read:base)?
Sometimes, I feel too jittery to sleep properly. I've found talking to people really helps with calming my nerves.
Telling him anything whilst he is dead by odonghs is pointless, don't you think?
Discovering the cure without telling him won't do much either.
I believe there's also some specific dialogue options during that night that may kill him even with the cure in mind.
Pretty demanding ♥♥♥♥♥ this Rubin.