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By the time you reach level 14/15 consider another 3 backpack slots.
You also get another slot for guns so you can carry 3 at all times, vary your weapons usage to balance the ammo side of it, plus open chests for ammo, dont skip em or you will get into the situation of not having enough and run out as you explained.
Pickup as many weapons as you can find and sell em, if they are not what you want.
Constantly upgrade your weapons/classmods/shields and dont be afraid to spend money on the vendors early game as some of the gear is better than what you find.
Dont spray and pray, use your ammo conservatively, in otherwords pick your shots as much as possible.
Sal is a pistol guy, he does not require machine guns, he can use smgs/ shotguns and snipers very effectively as can all the other characters.
if he has GOTY he starts with the Contraband Sky Rocket grenade mod, which usually is a terrible mod because its hard to aim and after it goes a certain distance it just shoots up into the sky, so in an open area it usually does litterally 0 damage to anyone, but its damage is based on the character level, so for tight spots its AMAZING (if you dont get caught in the blast). just run up to the door Midgemong comes out of, and lob one of those grenades in there as soon as the door opens.
if you do it right you can kill him one shot with any character as long as your level 5 or more (should be 5 or 6 by time you fight him anyway).