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Anyway, you can try using Dual Display Mouse Manager:
http://ddmm.sourceforge.net/
Basically it keeps your mouse locked to one screen. I've used that to fix other games that don't employ proper mouse screen-locking. It's not going to solve the problem when FO4 sometimes registers a "click" to applications behind the full-screen game, but it'll at least prevent your mouse from drifting to the other screen.