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Just play it in borderless fullscreen if normal fullscreen doesn't work.
Clean install of Nvidia Drivers.
Reboot
Run GeForce Experience
Wait for it to scan your games
Hit "Optimize" in the list for Fallout 4.
Then it will run full screen.
bMaximizeWindow=1
bBorderless=1
bFull Screen=0
iSize H=1080
iSize W=1920
If you don't want 1920/1080 resolution replace with your own. That's it, you will now be able to run Fallout 4 perfectly in Full screen with the above mention fix.
Excellent and also good advice AuroraWolf.