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% chance to cripple limb for high health bosses.
Welcome to easy mode
Exploding or Wounding shotguns. Both exploding and wounding add damage per pellet that they would for a full projectile from any other gun, making shotguns very efficient here. Also, the added damage is not reduced due to range. Both are also excellent at +dps for automatic weapons (gatling laser, flamethrower, whatevs) if you don't mind the relative ammo-inefficiency of automatics.
Furious automatic weapons -- damage increases per consecutive hit on same target.
Instigating semi-automatic/bolt action rifles. Double damage if target is at full health -- stacks neatly with sneak-attack bonuses, weak spot, Rifleman, Ninja, Sandman... extremely powerful if you have other modifiers to improve that first-hit damage and you have a suppressor to make it easier to make additional sneak attacks on other targets.
Kneecapper weapons are worth a look -- they're not really OMG ROFLSTOMP general-purpose weapons, but the 25% chance of crippling a leg even on a shot to center of mass is excellent if you're being charged by a pack of ghouls or a Deathclaw. Deathclaws are trivialized if they're literally reduced to a crawl. If you're using them just for this and using another weapon as your primary damage dealer, the per-hit cripple chance is independent of weapon damage or ROF, so a lightweight 10mm kneecapping pistol converted to a full-auto would be better for this role than a kneecapper .50 cal rifle.