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I'm only doing the radiant quests.
The repeat quests are unimportant. I was referring to a specific BoS line Main Quest mission.
The game basically slams a sign in your face "[Faction] now hates you!" when you accept the mission
No worries then. :) You have to meet all three I recall before you get that mission.
No prob. o/
However when you start doing some quests for Instute evetually Railroad leader tells you go **** your self or they shoot you if you go speak to them when you have reached that certain quest Mass Fusion .
As long as you do not take any actions that would anger the brotherhood.
If you blow up the Pigwhen, you can't join the BOS
If you've taken The Castle for the Minutemen, you can integrate Raiders into the Commonwealth while still being the General, but it will lock you out of Preston.
Desdemona will have a dialogue where she asks about your true allegiance at one point, just walk away to keep your standings intact
For Institute, you can accept "Mass Fusion" but advancing it will lock you out of BoS/Railroad
Prior to mass fusion there are some quests that won't be available depending on what quests you do first. I haven't compiled the list of those quests yet, but there are quite a few. And most of them if I understand correctly are tied to the main story. Such as Molecular level.