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use perks :-P
Most weapon damage comes from your chosen perks also.
I've heard the sawed off with the Never Ending Legendary mod is quite broken too, but I still would think an explosive combat shotgun or a Two-Shot combat shotgun would top anything.
To maximise damage on a combat shotgun, invest into these perks:
Rifleman rank 5 (+100% damage)
Lone Wanderer rank 3 (+25% damage)
Mister Sandman rank 3 (+50% damage if you mount a suppressor to it)
Bloody Mess rank 3 (+15% damage)
Lady Killer/Black Widow rank 3 (+15% damage to the opposite sex)
Nerd Rage Rank 3 (+40% damage when your health is 20% or below)
Use Pyscho or its variants for another +25%