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If you joined the Minutemen already, you could still do the Minutemen ending while still allied with the NW raiders.
You can never be permanently hostile the Minutemen.
It’s the Institute quest to retrieve the scientist from that house southwest of Grey Garden, “Pinned” I believe is what it’s called.
If you’ve become General for the Minutemen and have done some of their quests, and embark on this quest for the Institute, you’ll have a confrontation with the MM who have also come to rescue the scientist.
Depending on the choices you make and your charisma level, you’ll either end up betraying the Institute, pissing off the MM, or working things out in a non-confrontational way.
I also believe it’s possible to go to war with the Brotherhood of Steel from the side of the MM if at any point you’ve become hostile with the BoS.
I’ve never done it myself but I’ve seen people mention that it’s possible and results in an assault on the airport that has you use the MM’s artillery to shell and destroy the Prydwen.
If this is true though, I’m fairly sure it doesn’t work both ways. There is no point during the BoS questline where you have to attack the MM or choose which one you want to support.
Regardless, as others have said, the MM are the “safety net” faction. They cannot be destroyed, and while Preston can hate you and refuse to be your companion, the MM won’t kick you out of their group and strip your General status away and start treating you as hostile on sight (although, MM NPCs will become hostile if you’re attacking MM settlements during the Nuka World raiders missions).
It results in some weirdness that doesn’t make a lot of sense, but I guess BGS wanted to “idiot proof” the game and avoid players locking themselves out of being able to build the Molecular Relay, and ultimately complete the game (as the third act is pretty much just you picking a faction and finishing the story).
Gage > Preston, easily
The main exception that comes to mind is with the Far Harbour DLC ones to destroy the different factions, which I left unfinished since I intentionally chose the alternative and they just don't shut down. The way the options to destroy both Far Harbour and the Nucleus remain open until you do them makes it feel like Bethesda's canon there is supposed to be destroying everything except Acadia (or maybe Acadia as well, but the core game's main story favours the Minutemen and Railroad over the Brotherhood and Institute).