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Every time you use a chem, the game adds the UMON score of the chem to your current total and rolls a check. That check is against the flat percentage chance of addiction for the chem, modified by your current UMON score. Your UMON total goes down with time, but AFAIK cannot be reduced directly. You need a lot of UMON score for it to start significantly upping your chance for addiction. Popping jet in every encounter will quickly pile up UMON and your chance for addiction, but using mentats every day right before you do a bunch of crafting won't make any real difference.
TL;DR: Use lots of drugs often, get addicted more often. If you find this takes the fun out of the game for you... Change it up! Go to the docs and get cleaned up more often, carry addictol, or just live with the addictions and feed them as you go... Maybe get a Junkie's weapon or two. I use Jet all the time when I don't have companions/am traveling with companions who don't care, and I keep buffout and psychotats for really difficult encounters.
https://www.youtube.com/watch?v=Aqg-qY0ZCMA
Ada is so refreshing, with her finally I can do whatever I please!
So, personally, i don't even consider Fixer an option, and as such i think FO4 has WAY easier access to removing addictions. It becomes pretty easy even early on to develop a sizeable stockpile of Addictol and/or Refreshing Beverage, so that's 2 super easy on-the-go options for removing addictions, plus any doctor you happen to find
in closing: ♥♥♥♥ Fixer!
sorry... i may be a little bitter
Took Jet at level 21 once
At level 40-something I took it again (at least a whole day solid IRL of time playing)
Took it a third time at level 98 recently, got addicted to jet.
It seems almost to be more like total taken, meaning you seemly never reset to 0 unless you get cured.
More frequency seems to give it faster, but otherwise, no escape.
To be honest, I couldn't care much.
Really easy to get cured from additions in F4.
Or just wait them out with the wait key. You don't have to suffer through them.
Again, all addictive chems have a flat percentage chance each time you use them of causing addiction. Yes, this means you can become addicted to a chem the first time you use a chem ever. The only way to circumvent this is with the appropriate perks.
Bethesda's UMON system in action, as I detailed above.