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Explosive Combat Knife
Explosive Gauss Rifle
Poisoned Switchblade
Penetrating Gauss Rifle
Troubleshooter's Gamma Gun :3
Bleeding Fisto (that sounds very wrong somehow...)
Troubleshooter's Fisto
Ghoulslayer's Shotgun (either type)
Violent Gauss Rifle
Violent Fat Man
Also an irradiated flamethrower or plasma sprayer
I'm a big fan of furious automatic guns, and Instigating Gauss Rifles. I prefer them to two-shot as the second shot sometimes misses and doesn't do full damage. With instigating, you're always doing double damage to full-health targets which with my perks kills any human I've run into in one stealth headshot.
2 shot .45 Combat Rifle
Double Damage when target is at full health silenced 10MM pistol (great for sneak killing)
those are really my 3 favorite to use