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The Institute not knowing about Acadia at all suggests they didn't deliberately release mutants there, though there's more of a question mark over whether or not these mutants were Institute-made in the first place.
But it does pose a bit of a puzzle about how they got there either way, unless we believe an entire group of super mutants just decided to swim over from the mainland. It's possible they saw boats moving around the Island and just followed them back.
Why would they do that, given that the Institute made these Supermutants as attempted replacements for Type 2 synths?
The mutants on the Island would look the same as those in the Commonwealth because the Institute's samples originally came from the same source.
They move around. They are not stupid. They don't just stand there rooted to the spot where they were made.
But spreading to the Island in large enough numbers to establish a permanent presence suggests either a big coincidence (they just happened to go where the Sole Survivor later ventures) or some kind of big super mutant diaspora, beyond what we could expect from the Institute. Making enough mutants to decently populate areas stretching out hundreds of miles from the Commonwealth would have depopulated their local region.
But how did they get there. A bridge? Did the bridge fall in the 2077 war because Institute brand (tm) supermutants started creation 90 years after the war.
There are some remains of a bridge along the northern edge of the Island if I remember correctly (somewhere near the oceanarium), but I don't know exactly when it's supposed to have collapsed.
They can be from anywere were mutants were Created... and its not that hard, even for a mutant, to cobble something together that can stay afloat.
True enough, these SM build shacks and set traps.
The island is a real-world island, and its not that far off the coast (about a half a mile, or 0.8km). And there is a smaller island in between. They could walk most of it, even if the bridge was destroyed.
We know there are some SM with superior intelligence. All it would take is one leader to recognize the value of exploiting an island full of food and resources. Short of that, even one moron who accidentally got lost could have made his way back to the mainland and passed the word along. They are powerful and like radiation... they could go anywhere a log could float.
Most importantly, it's just a video game. Expecting rock-solid lore and logical consistency is not reasonable... there are mutants there for us to fight.
tl;dr translation... Some folks are obsessing over minutiae.
The master was west coast and has no relation to anything in 3 or 4 neither do his mutants.
FEV was created by west tech as a panacea meant to render humans immune to all diseases and specifically the ongoing new plauge pandemic.
The side effects caught the attention of the military who siezed the research and begun conducting experiments at various sites across the USA. The master came about post war when Richard Gray and his team well investigating mutant animal attacks found Mariposa and were exposed but the farthest east his army got in any numbers is Chicago