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Grab the charisma bobblehead if you haven't already, although it's one of the hardest ones to get.
The investments in Local Leader "may" eventually get you to a point where you have all the traders in all your settlements, so you can buy copies of Shipments (weightless) for all junk, but that is far ahead.
You can "mark" hotkey specific junk so it will glow when you are near it, this is useful for those junks you use the most, like adhesive and other that are rare or hard to find.
And scrap worthless items. If you have Scrapper Perk it is a solid invesment for Survival, it yields a lot of useful items when you scrap weapons and armour that have mods on them.
Local Leader is a comfort perk to link your crafting resources from one settlement to another, that saves you the trouble of moving your resources manually.
Remember that some vendors sell junk (an easy accessible duo would be Trudy and Trashcan Carla near Concord), and it's relatively cheap. You can also sell your abundant resources like steel to make some easy money and invest it to buy better quality junk. Else scavenge all your heart's content in dungeons!
Heavily modified weapons can be scrapped for more advanced materials like aluminum, so pick up the modded stuff. You can scrap these at weapon stations you find around the map. You can sell the wood and steel to whatever vendors you come across.
Most of us keep a mental list of which junk items contain useful parts like nuclear material or fiber optics. If you need one thing in particular, the Fallout 4 fandom website usually recommends a good spot for finding it.
It's cheaper to regularly buy and scrap tape and glue than it is to buy an adhesive shipment. I don't know if that's true for other materials.
Local Leader is another must have.
Strong Back — max out to fast travel over-encumbered, unless you play on survival.
Then you can strip the place off anything not nailed down and still be able to run and fast travel while carrying enormous amounts of junk.
Be on the look out for junk with a variety of components; cameras, typewriters, telephones, etc. Buy them from vendors any chance you get. Don't bother with junk items that are mainly steel, wood, and cloth; those materials are superfluous within your own settlements.
Local Leader is a must have for three reasons; It helps you pool resources, enables you to craft workbenches and shops, and is essential for managing multiple settlements.
If you are going to be mostly buying junk,
- improve your CHA
- get and wear gear that improves CHA - there will be some in Sanctuary, more to be found from loot and vendors
- find skill magazines that increase barter
- get the Speech Bobblehead from rescuing Nick
- for big transactions use chems/alcohol to increase CHA (but beware of addiction)
Good point. Which is one reason doing the Vault 88 quest, is so valuable. Concrete and Nuclear Material.
Until you can afford to turn Sanctuary into a high production center for Purified Water you can use all the steel you find to make Poisoned Caltrops and sell them. Then you buy all the shipments of steel you can find until you run out of money and start the same process again. Rinse and repeat a couple of times to make lots of money. Use that money to buy shipments of whatever crafting materials you need. Use those to turn Sanctuary into a Purified Water factory. Get even richer by selling all that Purified Water and never have to worry about picking up any junk item ever again.
Regarding mods: if you want to use that method it would be a good idea to get a mod that increases the amount of caps the vendors have or selling all that stuff will become very tedious. There is also a mod that makes junk items weightless so they have zero weight. Oh and crafting all those traps at the chemist station will give you lots of XP. It's only 3 XP per trap but since you will probably craft hundreds of them you will get a couple of levels out of them.