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You just have to avoid any face to face combat with ghouls and molerats ect. because they spread illness or try to sleep as much as possible on beds because sleeping bags and mattresses can cause parasites ect... Also try to cook your food and water before eating it and buy or craft Herbal stimulant, Herbal antimicrobial, Herbal anodyne because those boost your immune system so you don't get sick so easily.
Sleep in your own bed under shelter.
Certain Illnesses aren't really worth curing, and auto-resolve on their own. The ones you should definitely cure ASAP early game are:
Weakness (20% Additional Damage taken)
Infection (Damage over Time, 20HP per game hour I think?)
Fatigue (Induces rapid tiredness which can compound in debilitating effects)
Other diseases like Insomnia, Lethargy, parasites aren't really that big a deal. All illnesses aside from Parasites will heal themselves after about 1 week in game time, unless you have < 3 END.
"Expsoure" can cause illness too, this includes any and all radiation sources, as well as RAIN.
Do you have a source for this? Because assumed that would be the case but it didn't seem to make a difference. I then went googling and everything I read so far says END does nothing against diseases. My experience so far seems to confirm this, as I've been raising my END from 5 to 9 and if a Ghoul looks at me funny I'm diseased.
It's perfectly possible to avoid disease almost entirely just through behaviour.
Get plenty of sleep. Eat and hydrate before you sleep. Stay out of the rain. Don't swim. Don't let critters mêlée you. Avoid using chems. Eat only cooked food you made yourself.
If you do those things you will be fine. It's mainly about adapting your behaviour away from habits you learned in non-Survival. Which is generally true of Survival, across-the-board, not just in relation to avoiding diseases.
If you get a disease you can just ride it out. Stockpile clean food and water ahead of time. Have a water pump near to your bed. Sleep 24 hours a day until the disease is gone. Even Infection won't kill you.
If you want a long read, here's all my research on Disease from last year.
https://steamcommunity.com/app/377160/discussions/0/1639787494957824281/
https://fallout.fandom.com/wiki/Survival_mode
https://fallout.fandom.com/wiki/Condition#Illness
The Weakness disease causes you to take more % damage, and the Infection disease causes fixed HP damage at intervals. So higher END, giving higher HP, will make these diseases more survivable, particularly Infection which is definitely the most dangerous disease.
I had mistakenly expected, as others might have, that END would factor into how likely you are to get sick or how long diseases would affect you. It does none of those things.
The indirect effects of END are mixed, in my opinion. Infection will be less threatening as it is a flat damage source, but weakness will hurt you more as you have more to lose from the increased damage (amplifying damage is like reducing your HP in a % basis).
It sucks in a special way if you are making a melee character because you will get diseased a lot. Doesn't help that through perks you can become resistant to shots to the face and eat radiation for health but you can't avoid diseases, wish there was a mod for that. I was going for a hulking barbarian but it feels more like hypocondriac body builder with all those antibiotics and remedies.
Plus the endurance gives you access to health benefits like adamintium bones, so you can increase your carrying capacity by not having to strengthen your leg armor--another health benefit. I automatically do all this without even thinking about it now--one reason the game's become so boring. I'm trying to put some hours in other games lately so, hopefully, I'll forget all this; the game will become harder; and it'll be more interesting.
I agree the role of END is counter intuitive. I think the SPECIAL video even says it helps with diseases, but it really doesn't. Not even via Perks.
It does help directly in Fallout 76, reducing disease probability.
I hadn't thought about the melee issue but you are right. Melee characters are going to get bit and there's no compensating Perk. Though you can see that if there was such a Perk it would be a Survival only Perk, unless it had other affects in vanilla.
Carry lots of chems I guess. A legendary armour effect (disease resistance or immunity) would have been nice. Even PA doesn't reduce your chance of infection from a bite. Even if you sustain zero damage, I believe.