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Ooookay, here's my 2 cents.
Beth devs are known for messing things up a lot. Douglas doesn't agree with me on that but for me it's a clear oversight they forgot to disable VATS until you put on that Pip-boy.
My opinion is pretty much same on synth components. First they try to be thorough to the point where they put synth components on essential NPCs (obviously you can't loot that component without mods/console commands but it is there for some reason) and then they don't put synth component on those who are confirmed to be synths). Again, there're other opinions but mine is that they just effed this up.
Now, there's a curious bit on synth lore that comes from Fallout 3. In Fallout 3 you can learn the story of A3-21 who fled to Capital Wasteland. A skillful scientist from Rivet City decided to help the Railroad and agreed to perform plastic surgery and do memory wipe on the synth. He successfully performed plastic surgery, extracted the synth component and gave the synth new memories but instead of wiping the synth's old memories he locked them and made a code for restoring them. If Lone Wanderer learns the code they can choose to unlock A3-21's original memory so he gets two sets of memories in his brain.
From this piece we can learn that synth component can be extracted by skilled specialist and it doesn't kill synth. Second, apparently synths can still accept commands without synth component.
By studying synth settlers one can learn that not all synth have innate resistances. I assume synth Art got some kind of subdermal plating or something else to boost his resistances.
Conclusion: there're synths in game that don't have innate resistances and don't drop a synth component, the latter can be an oversight or they could be indeed assembled without one intentionally or due to sabotage or malfunction of assembly line.
Without an explicit statement from the developers that something was an oversight, you need blatant evidence of it (like visible glitches, or something being nonsensical no matter what explanation you try), especially when it's something that fits with a possibility hinted at by the game (by Institute terminals describing a direct equivalent, DiMA in Far Harbour suggesting precisely the same scenario, and the main story prominently featuring the concept of an original person being replaced by a synth).
As for DiMA, he isn't exactly a trustworthy source. He's an outdated prototype with questionable hardware installed on top of experimental hardware. What he seems to be interested in is preserving the community of synths he founded. He is ready to kill for his community so lies would be the lesser evil in this case. If DiMA is sincere when he talks about what can indicate that a person is a synths he still only makes some guesses and he guessed wrong with Kasumi. If you play as Nora your character also lies about her first memory, choosing certain dialogue options in the prologue leads to Nora's sarcastic reply that clearly shows she remembers the events that led to her pregnancy and birth of Shaun.
Btw, a DNA test can tell if a person is a synth or not. It is stated that Shaun's DNA was used as a base for Gen3 synths so getting samples from Nate and Nora (and Shaun, if possible) and then comparing them to a sample from a suspected person can give a clear answer without killing the suspected person.
As for conflicts, given that it's a mental effect (at least for the Institute VATS) allowing the user to effectively visualize the chances of hitting, the Sole Survivor would just end up combining the overlapping sources of information. Of course, the Pipboy's VATS might not even be working; it's not like you'd notice the absence if you already had the required function from a different source.
It's not just about DiMA's validity as an in-game source, but the fact that the idea of the player potentially being a synth is already defined as an in-game possibility (along with people secretly being synths already being a core part of the main story). This provides a scenario in which a subtle hint that the player could be a synth (with VATS before getting a Pipboy) exists in an environment where the idea of being a synth is already entrenched. Something that hints at a possibility the game already obviously supports as a concept is not "clearly" an oversight in the same way as a concept that otherwise didn't exist in the story.
Whether or not Nora is lying about (or forgetting) earlier events isn't especially important here, since a synth copy would similarly have those memories. And DiMA was addressing the generally incomplete nature of the Sole Survivor's memories, not just the details of a particular event. A proper rebuttal of DiMA's point would have involved the Sole Survivor showing him that they had a clear and extensive memory of their life.
Synths have individual DNA, which is how the Brotherhood of Steel identifies Danse as a synth using the Institute records we retrieve. They look at the records and find that their subject matches the specific DNA records for one of the listed synths. If synths all had identifiable synth DNA, the Brotherhood would have already been able to reliably test for synths.
Shaun's DNA was studied for the developement of Gen 3 synths, but they're not simply clones of his DNA.
For example: if you suspect someone being a synth, feed them fancy lad snack cakes. Alot of them. For a couple of months.
Not only do synths for some reason LOVE fancy lads, But according to institute logs, they can't get fat off them.
So if you got somebody locked up, feeding them high suger fancy lads for 2-3 months and they havent put on a bunch of pounds, Their likely a synth.
Not foolproof but deff something to build off of.
Another thing is something covenent built off of: Apparently synths have trouble answering some manners of alghorithisms.
Third, and most extreme, Would be to simply cut down to the bone and Examine it. Synth bones are synthetic and not actually made of bone. so if you sliced open someone's arm and examined the bone structure, you could tell.
And lastly, it isn't suggested in-game, But with the knowledge that synths carry a kind of component ether in their heads or spine, I'd design a device that can detect those components. Kind of like a metal dectector but for synth components.
That's basically like what Covenant is trying out.
I'm almost certain this one wouldn't work. While they may be synthetic, it's apparently close enough to a regular human to pass microscopic examination by the Brotherhood of Steel, who has at least enough technical expertise to perform DNA tests.
It might be possible, depending on the exact nature of the component, though some synths don't appear to have one.
You would also have to hope that it also isn't made undetectable by some kind of special phase shift or something (out of which it only emerges when the synth is killed), since it's built by the same people who developed the molecular relay.
Depending on how the molecular relay works, there's also a possibility that it does sanitize travellers of stray particles (not that I think this is necessarily done deliberately to foil tracking).
It's going to be difficult to train the dog though, since you need reliable samples for that, and we're not just talking about detecting a specific substance as you might with a drug-sniffing dog. I mean, are you going to have the dog randomly maul people to death and reward it every time one of them has a synth component?