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Other option would be to just copy save files from default location to named folders and swap those folders in to Documents > My Games > Fallout 4, based on which character you want to save. It is an option, though somewhat more troublesome, compared to just changing a profile in manager.
I actually use three profiles at the moment
1 unmodded
2 simsettlements and related mods
3 one for alt start/end type mods.
Occasionally a temp 4 profile to test out some mods that might cause issues before deciding on using them with my main game profile or not is used.
Unless I missed something when I initially started using profiles, it does however have the ability to copy an existing profile to a new one.