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They are the best choice for a VATS and crits heavy playstyle, because pistols require fewer action points to fire. Couple that with high luck and you're good to go. You can do pretty much all the game with Righteous authority turned into a pistol
Pistols are the way to go at higher levels and modded games for super tough and thick enemies.
Both have their place.
Give me a pistol in close quarters and a rifle at 300+ yards.
The game is what you make it.
problem is that the constant lacking of ammunition for large weapons, my handguns turned to be an all around universal weapon for everything, and now im really struggling
10 mm can dispatch pretty well .. and the ammo is very comon.. cheap..
Even Caesar himself wore his proudly.
Seriously though, pistols like the 10mm fire super fast, don't have a ton of recoil (once you deck them out), and headshots take things down super quickly. You just have to be hitting headshots for the +100%(ish) damage.
I find the high damage/low firing rate pistols like Kellogg's to be near useless against spongy enemies, as you'll take a ton of damage between shots, but fast pistols - even the pipe - are great for fast kills. Again, just make sure you are shooting them in the head.
Works even better with any of the locational damage mods, including Live Dismemberment (which is probably the most awesome mod in FO4 anyway).
just a suggestion....
https://www.nexusmods.com/fallout4/mods/18796
As to the tougher enemies in Nuka World, either a laser gatling or gauss rifle handle them.
Gatling uses fusion cores, gauss rifle uses 2mm, I haven't had problems finding either.
So, when you invest in the perks Gunslinger, Gun Fu, Four Leaf Clover, Grim Reaper's Sprint, Critical Banker, and Better Criticals, you'll have yourself a VATS-based gun build that can clear an entire room of enemies with nothing more than a 10mm pistol.
Wrong. The gatling laser uses fusion cores which are the most cost and weight efficient ammunition in the game. Final Judgement (rapid legendary) is easily god tier, and I'd rank it at, or near, the top. The minigun is god tier as well with explosive, and quite cheap to keep fed.
The only thing to out damage a rapid gatling laser is a junkie gatling laser, if you're willing to deal with addictions. Obviously explosives like the fatman/ mirv will beat it but are rare, and heavy as sin.
Edit: Take nuclear physicist to extend the use of fusion cores. You get an additional 125 shots per core at no extra weight. Just leave a single shot in each one and sell them for max efficiency and profit. My power armor and gatling laser paladin from level 5 to level 290 never had to leave his suit nor use any other weapon as the game throws cores at you.